TABLE 2.
Tissue distribution of viral antigen and inflammatory reactions following the intracerebral inoculation into neonatal ddY mice of the original Saffold virus strain (AM) or the strain passaged in mouse cerebellum (AM-5Cb)
| Virus strain and day of sacrifice p.i. | No. of mice | Central nervous system tissuea |
Peripheral tissuea |
||||
|---|---|---|---|---|---|---|---|
| Cerebrum | Brainstem | Cerebellum | Spinal cord | Muscle | Peripheral nerve | ||
| AM | |||||||
| 3 | 3 | 3/0 | 3/0 | 3/1 | 1/0 | 2/0 | 0/0 |
| 5 | 3 | 3/0 | 0/0 | 3/0 | 1/0 | 3/0 | 3/0 |
| 7 | 3 | 1/0 | 0/0 | 3/0 | 1/0 | 1/0 | 0/0 |
| 21 | 7 | 0/1 | 0/2 | 0/0 | 0/0 | 0/0 | 0/0 |
| AM-5Cb | |||||||
| 3 | 3 | 3/0 | 3/0 | 3/0 | 2/0 | 3/0 | 3/0 |
| 5 | 3 | 3/2 | 2/0 | 3/3 | 2/0 | 2/0 | 3/0 |
| 7 | 3 | 3/1 | 2/1 | 2/0 | 3/0 | 3/0 | 0/0 |
| 21 | 7 | 1/7 | 0/4 | 0/3 | 0/4 | 0/5 | 0/0 |
a
Values represent the number of animals positive for viral antigen/number of animals positive for degeneration or inflammatory reactions.