FIG 6.

Genomic organization of proteins detected in viral factories and mature virions. Our proteomic analyses indicate that the majority of proteins found in the viral factories of mimivirus are encoded by genes located in the center of the mimivirus chromosome. This observation is consistent with previous findings according to which mimivirus virions propagated under axenic conditions undergo substantial reduction of their genome that specifically occurs at the extremities of the genome and yet is not detrimental to mimivirus infectivity (35). CDSs (coding DNA sequences) are represented as blue arrowheads. Proteins detected in VFs at 4, 5.5, and 7 h p.i. are labeled in blue, purple, and maroon rectangles, respectively. Proteins found in mature mimivirus particles are labeled in green. The linear mimivirus genome is depicted as a circle starting from the site indicated by an arrow. The figure was constructed with the CGView Comparison Tool (CCT) (46).