TABLE 1.

Properties of viruses used in this study and the effects of DFMO

Virus	Family	Genus	Sense	Envelope	Segmented	Effect of DFMO (fold reduction in titer)a	Cell type
Chikungunya virusb	Togaviridae	Alphavirus	+	Yes	No	200**	BHK-21
						8*	Murine fibroblasts
						12**	Vero
						12**	Human fibroblasts
						28*	C6/36
Sindbis virus	Togaviridae	Alphavirus	+	Yes	No	10***	BHK-21
MERS coronavirus	Coronaviridae	Coronavirus	+	Yes	No	30***	Vero
Dengue virus, serotype 1	Flaviviridae	Flavivirus	+	Yes	No	60***	BHK-21
Zika virusb	Flaviviridae	Flavivirus	+	Yes	No	15***	BHK-21
Japanese encephalitis virus	Flaviviridae	Flavivirus	+	Yes	No	5**	BHK-21
Yellow fever virus	Flaviviridae	Flavivirus	+	Yes	No	90*	BHK-21
Enterovirus A71	Picornaviridae	Enterovirus	+	No	No	12*	HeLa
Coxsackievirus B3	Picornaviridae	Enterovirus	+	No	No	10*	HeLa
Poliovirus	Picornaviridae	Enterovirus	+	No	No	20*	HeLa
Rift Valley fever virus	Bunyaviridae	Phlebovirus	−	Yes	Yes	200***	BHK-21
Vesicular stomatitis virus	Rhabdoviridae	Vesiculovirus	−	Yes	No	20**	BHK-21
Rabies virus	Rhabdoviridae	Lyssavirus	−	Yes	No	2***	Cortical neurons

^aCalculated by dividing titers from untreated cells by titers from DFMO-treated cells. Statistical significance was determined using a one-tailed Student's t test to compare the results for untreated and DFMO-treated cultures. *, P < 0.05; **, P < 0.01; ***, P < 0.001.

^bAs described previously (4).