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Demonstration of antiviral activity against multiple CHIKV strains and ONNV. CRL-2522 cells were infected with Gluc-tagged versions of CHIKV isolates LR2006 OPY1, SGP11, CNR20235, and ONNV at an MOI of 1. Berberine was added for 24 h, and Gluc activity was detected by luminescence signal. Percentage inhibition values were expressed relative to signals from untreated infected cells. Luciferase signals were measured from triplicate wells, and data are presented as means ± SEM (n = 2).
