Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic presentation of the mechanism of cell apoptosis induced by 2B. 2B encoded by EV71 is targeted to the outer membrane of the mitochondrion. Its N terminus is exposed on the membrane surface, interacts with Bax, and recruits Bax to the mitochondrion. The interaction between Bax and 2B induces the conformational activation of Bax and exposes its BH3 domain. Bax forms homo-oligomers that trigger the release of the caspase-activating protein Cyt c and induce cell apoptosis.
