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Antigen-specific cIL-10 levels correlate with chronic viral shedding in saliva. cIL-10 levels secreted by RhCMV antigen-stimulated PBMC (2.5 × 106) isolated from persistently infected macaques were plotted relative to concomitant RhCMV genome copy numbers per milliliter of saliva (r = 0.4476, P = 0.03345; one-tailed t test). Data represent results for samples from weeks 21 (10 animals only), 22, 28, and 34. The limit of detection for RhCMV was 1,000 copies per ml of saliva.
