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. Author manuscript; available in PMC: 2016 Oct 18.
Published in final edited form as: J Invest Dermatol. 2016 May 7;136(8):1656–1663. doi: 10.1016/j.jid.2016.04.022

Figure 1. LCE 1 proteins contain Gly/Ser loop motifs and are candidates to compensate for the loss of Lor in LKO mice.

Figure 1

Lce genes are clustered in the EDC and share similarities with both Lor and the Sprr gene family members. (a) Localization of Lce genes in the EDC of chromosome 3 (NCBI build 37.1). The arrows indicate the direction of transcription. The red arrows indicate the Lce1 genes. S100, S100 calcium binding protein gene; Kprp, keratinocyte proline-rich protein gene; Crct1, cysteine-rich C-terminal 1 gene. (b) LOR has multiple unstructured Gly/Ser loops surrounded by conserved glutamine and lysine residues that serve as cross-linking sites for transglutaminases. SPRR2 proteins lack Gly/Ser loops, instead, these proteins are characterized by long stretches of proline and lysine residues. LCE1 proteins resemble both LOR and SPRR2s in their amino acid sequences and the presence of proline and lysine motif as well as two Gly/Ser loop motifs. EDC, epidermal differentiation complex; FLG, filaggrin Gly/Ser, glycine/serine; His/Arg, histidine/arginine; LCE, late cornified envelope; LKO, loricrin knockout; LOR, loricrin.