Table 2. DVR (2TCM method) and DVR' values (Logan method) for each brain region (pharmacokinetic analysis population).

	DVR (2TCM method)		DVR' (Logan method)
	HV (N=16)	MDD (N=14)	HV (N=22)	MDD (N=20)
Dorsal caudate
Left
Mean (s.d.)	1.64 (0.28)	1.68 (0.29)	1.65 (0.19)	1.70 (0.18)
P-valuea			<0.001	<0.001
Right
Mean (s.d.)	1.60 (0.24)	1.65 (0.33)	1.61 (0.17)	1.64 (0.20)
P-valuea			<0.001	<0.001
Dorsal putamen
Left
Mean (s.d.)	1.71 (0.26)	1.77 (0.27)	1.73 (0.19)	1.77 (0.18)
P-valuea			<0.001	<0.001
Right
Mean (s.d.)	1.71 (0.24)	1.80 (0.28)	1.74 (0.16)	1.79 (0.18)
P-valuea			<0.001	<0.001
Ventral striatum
Left
Mean (s.d.)	1.78 (0.27)	2.02 (0.70)	1.74 (0.21)	1.79 (0.20)
P-valuea			<0.001	0.748
Right
Mean (s.d.)	1.71 (0.23)	1.81 (0.36)	1.70 (0.16)	1.73 (0.21)
P-valuea			<0.001	<0.001
Hippocampus
Left
Mean (s.d.)	1.67 (0.31)	1.73 (0.27)	1.58 (0.16)	1.63 (0.19)
P-valuea			0.020	<0.001
Right
Mean (s.d.)	1.62 (0.24)	1.67 (0.36)	1.56 (0.16)	1.57 (0.20)
P-valuea			<0.001	<0.001
Amygdala
Left
Mean (s.d.)	1.69 (0.22)	1.70 (0.34)	1.64 (0.13)	1.65 (0.20)
P-valuea			<0.001	<0.001
Right
Mean (s.d.)	1.71 (0.23)	1.73 (0.32)b	1.65 (0.14)	1.67 (0.18)
P-valuea			0.001	<0.001
Cingulate
Left
Mean (s.d.)	1.62 (0.22)	1.74 (0.28)	1.62 (0.16)	1.69 (0.16)
P-valuea			<0.001	<0.001
Right
Mean (s.d.)	1.63 (0.22)	1.70 (0.22)	1.64 (0.15)	1.69 (0.12)
P-valuea			<0.001	<0.001
Temporal lobe
Left
Mean (s.d.)	1.74 (0.23)	1.78 (0.25)	1.70 (0.16)	1.75 (0.14)
P-valuea			<0.001	<0.001
Right
Mean (s.d.)	1.76 (0.23)	1.80 (0.23)	1.72 (0.16)	1.76 (0.14)
P-valuea			<0.001	<0.001
Parietal lobe
Left
Mean (s.d.)	1.59 (0.17)	1.64 (0.23)	1.60 (0.11)	1.63 (0.13)
P-valuea			0.006	<0.001
Right
Mean (s.d.)	1.60 (0.17)	1.64 (0.22)	1.61 (0.11)	1.65 (0.12)
P-valuea			0.007	<0.001
DLPFC
Left
Mean (s.d.)	1.60 (0.20)	1.66 (0.20)	1.60 (0.13)	1.66 (0.11)
P-valuea			<0.001	<0.001
Right
Mean (s.d.)	1.62 (0.20)	1.66 (0.19)	1.62 (0.13)	1.67 (0.10)
P-valuea			<0.001	<0.001
OPFC
Left
Mean (s.d.)	1.67 (0.21)	1.69 (0.20)	1.65 (0.15)	1.68 (0.11)
P-valuea			<0.001	<0.001
Right
Mean (s.d.)	1.68 (0.21)	1.70 (0.22)	1.67 (0.14)	1.68 (0.13)
P-valuea			<0.001	0.001
MPFC
Left
Mean (s.d.)	1.68 (0.21)	1.74 (0.25)	1.69 (0.14)	1.73 (0.13)
P-valuea			<0.001	<0.001
Right
Mean (s.d.)	1.68 (0.23)	1.71 (0.24)	1.68 (0.16)	1.71 (0.14)
P-valuea			<0.001	<0.001

Abbreviations: DLPFC, dorsolateral prefrontal cortex; DVR, distribution volume ratio; HV, healthy volunteers; MDD, major depressive disorder; MPRF, medial prefrontal cortex; OPFC, orbital prefrontal cortex; 2TCM, two-tissue compartment model.

^aP-values based on Pearson product–moment correlation coefficients between DVR and DVR'.

^bN=13, as for one subject the model did not converge.