Table 1. CON1 associations with schizophrenia features.

Phenotype measure	Beta	s.e.	P-value
SAPS: total populationa	−0.097	0.039	0.013
SAPS: childhood onset	0.15	0.15	0.22
SAPS: adolescent onset	0.003	0.06	0.70
SAPS: adult onset	−0.16	0.05	0.00155
SANS: malesb	0.16	0.07	0.0327

Abbreviations: SANS, scale for the assessment of negative symptoms; SAPS, scale for the assessment of positive symptoms.

Results from regression analyses of DUF1220 subtype CON1 copy number versus positive symptom score (SAPS), negative symptom score (SANS) stratified by age of onset. The stratified population description is available in Supplementary Table 2. P-values meeting statistical significance (<0.05) are in bold.

^aCON1 versus SAPS model includes SANS and age as covariates; age-specific models include SANS as a covariate.

^bCON1 versus SANS model includes SAPS as covariate.