Table 4. Summary estimates for the association of log ApoE concentration with cardiovascular events from the three studies.
| ApoE Concentration | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
| OR or HR (95% CI) | p-Value | OR or HR (95% CI) | p-Value | OR or HR (95% CI) | p-Value | |
| ASCOT | ||||||
| Per SD increase in log ApoE | 0.99 (0.89, 1.10) | 0.89 | 0.83 (0.74, 0.94) | 0.003 | 0.96 (0.85, 1.08) | 0.52 |
| Tertile 1 | Ref | Ref | Ref | |||
| Tertile 2 | 1.07 (0.84, 1.36) | 0.58 | 0.89 (0.69, 1.15) | 0.05 | 1.23 (0.93, 1.62) | 0.79 |
| Tertile 3 | 1.07 (0.83, 1.39) | 0.74 (0.56, 1.00) | 1.03 (0.77, 1.38) | |||
| ELSA | ||||||
| Per SD increase in log ApoE | 1.01 (0.90, 1.13) | 0.85 | 1.08 (0.94, 1.25) | 0.27 | 1.08 (0.95, 1.22) | 0.23 |
| Tertile 1 | Ref | Ref | Ref | |||
| Tertile 2 | 0.97 (0.74, 1.29) | 0.65 | 1.04 (0.75, 1.44) | 0.32 | 1.11 (0.84, 1.48) | 0.12 |
| Tertile 3 | 1.07 (0.81, 1.39) | 1.19 (0.85, 1.66) | 1.25 (0.94, 1.66) | |||
| NPHSII | ||||||
| Per SD increase in log ApoE | 1.08 (0.96, 1.22) | 0.20 | 1.03 (0.90, 1.19) | 0.66 | 1.09 (0.95, 1.25) | 0.21 |
| Tertile 1 | Ref | Ref | Ref | |||
| Tertile 2 | 1.24 (0.92, 1.68) | 0.23 | 1.53 (1.07, 2.17) | 0.51 | 1.41 (1.00, 1.99) | 0.16 |
| Tertile 3 | 1.21 (0.89, 1.63) | 1.16 (0.81, 1.68) | 1.30 (0.92, 1.84) | |||
Estimates are presented as the odds of cardiovascular disease per SD increase in ApoE concentration and as the OR per tertile of ApoE, where the reference group is tertile 1. p-Values represent a test of trend across ApoE tertiles. Model 1 is unadjusted; model 2 is Framingham adjusted; model 3 is LDL-C adjusted; ORs are reported for the ASCOT case-control subset and ELSA, and HRs are reported for the prospective NPHSII.
ASCOT, Anglo-Scandinavian Cardiac Outcomes Trial; ELSA, English Longitudinal Study of Ageing; HR, hazard ratio; NPHSII, Northwick Park Heart Study II; OR, odds ratio; SD, standard deviation.