Table 2. Table showing analytes altered in patients compared with controls.

Molecular function	Analyte	Abbreviation	Single analyte effects (logistic regression)				Joint analyte effects (LASSO selection)
			Coefficient	s.e.	P-value	Adjusted P-value	Coefficient
Lipid transport	Apolipoprotein H	ApoH	2.67	1.05	0.011	0.032	2.23
	Apolipoprotein A1	ApoA1	−1.48	0.66	0.026	0.062	−0.31
Inflammatory response	Macrophage migration inhibitory factor	MIF	2.89	0.48	1.75E−09	1.56E−07	2.76
	Carcinoembryonic antigen	CA	1.77	0.36	1.13E−06	1.68E−05	1.69
	Tenascin C	TNC	2.89	0.62	3.57E−06	3.97E−05	1.31
	Interleukin-10	IL10	3.55	0.83	1.70E−05	1.51E−04	3.63
	Interleukin-1 receptor antagonist	IL1ra	1.83	0.46	6.27E−05	4.30E−04	0.76
	Receptor for advanced glycosylation end products	RAGE	−2.01	0.52	1.10E−04	7.00E−04	−1.36
	Interleukin-8	IL8	2.30	0.62	2.12E−04	1.25E−03	0.67
	Haptoglobin	HAPT	1.38	0.37	2.30E−04	1.25E−03	1.23
	von Willebrand factor	VWF	1.69	0.56	0.003	0.010	1.66
	Alpha-2 macroglobulin	A2M	3.22	1.07	0.003	0.010	4.79
	Beta-2 microglobulin	B2M	−4.04	1.55	0.009	0.029	−4.59
	Serum glutamic oxaloacetic transaminase	SGOT	1.90	0.83	0.022	0.055	1.67
	Interleukin-13	IL13	1.32	0.67	0.050	0.103	0.19
Immune system	Immunoglobulin A	IgA	−1.54	0.63	0.015	0.042	−1.18
Hormonal signalling	Pancreatic polypeptide	PPP	1.97	0.34	4.12E−09	1.83E−07	1.80
	Leptin	Leptin	−1.55	0.28	5.42E−08	1.21E−06	−0.69
	Testosterone (total)	TEST	2.08	0.59	4.11E−04	0.002	0.86
	Follicle-stimulating hormone	FSH	1.17	0.34	5.19E−04	0.002	0.33
	Thyroid-stimulating hormone	TSH	−1.19	0.50	0.017	0.047	0.05
Growth factor signalling	Insulin-like growth factor-binding protein 2	IGFBP2	2.96	0.62	1.97E−06	2.51E−05	0.33
	AXL receptor tyrosine kinase	AXL	−2.35	0.82	0.004	0.014	−3.93
	Stem cell factor	SCF	−2.20	0.87	0.011	0.032	−1.72
Clotting cascade	Factor VII	FVII	−3.92	0.87	6.50E−06	6.43E−05	−2.71
	Angiotensin-converting enzyme	ACE	−1.39	0.67	0.037	0.082	−1.14
Hormonal signalling	Chromogranin-Aa	CGA	0.54	0.24	0.024	0.060	—
Growth factor signalling	Vascular cell adhesion molecule-1a	VCAM-1	−2.63	1.25	0.036	0.082	—
Inflammatory response	Eotaxina	Eotaxin	0.98	0.48	0.041	0.087	—

The analytes are ranked in the order of significance within each molecular function group.

^aNot selected by least absolute shrinkage and selection operator (LASSO) regression.