Table 2. Rare (MAF ⩽1%) nonsynonymous compound heterozygous genotypes in voltage-gated sodium channels.

Genotype	Bulgarian trios			Taiwanese trios			Combined sample P-value
	Probands N=604	Parents N=1208	P-value	Probands N=614	Parents N=1228	P-value
N VGSC CompHets (rate)	8 (0.013)	0 (0)	1.5 × 10−4	3 (0.0049)	9 (0.0073)	0.73	0.024

Abbreviations: compHets, compound heterozygous; MAF, minor allele frequency; VGSC, voltage-gated sodium channel.