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. 2015 Nov 3;5(11):e673. doi: 10.1038/tp.2015.160

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Whole-brain psychophysical interaction analysis with a right amygdala (a) and left amygdala (b) functional cluster (picture blocks versus baseline, across groups) as the seed region: patients showed higher connectivity of the right and left amygdala with left and right occipital pole, occipital fusiform gyrus, lateral occipital cortex and lingual gyrus. In patients, coupling between right amygdala seed and occipital cortex clusters and left amygdala seed and occipital cortex clusters was positively correlated with panic severity. Images thresholded at Z>2.3, P<0.05, corrected. *Significant difference between groups. Error bars show s.e.m. HC, healthy control; L, left; PD, panic disorder patient; R, right.