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. 2015 Nov 3;5(11):e673. doi: 10.1038/tp.2015.160

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Psychophysiological interaction analyses exploring connectivity of activity within the right amygdala (a) and left amygdala (b) as seed regions and a right dorsomedial prefrontal cortex (R dmpfc) region of interest. The right amygdala showed a task × group interaction in connectivity with the dmpfc, with amygdala–dmpfc coupling being significantly greater in patients relative to controls during Maintain blocks. No such significant interaction was found for the left amygdala seed. In patients, higher right amygdala–dmpfc coupling, as well as higher left amygdala–dmpfc coupling during Maintain minus Reappraisal blocks were associated with higher panic severity. *Significant difference between groups. HC, healthy control; L, left; MNI, Montreal Neurological Institute; PD, panic disorder patient; R, right.