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. 2015 Nov 3;5(11):e674. doi: 10.1038/tp.2015.166

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Response to DBS in the sucrose preference test. After baseline values were obtained, animals underwent 4 weeks of chronic unpredictable stress (CUS; week 3 was omitted for clarity). The post-operative measure was collected prior to DBS onset. vmPFC stimulation was delivered for 3 weeks from the second post-operative week. After surgery, a significant effect of treatment was found. On the second week of stimulation, sucrose preference in DBS-treated animals was significantly higher than in non-stimulated CUS rats. On DBS week 3, levels were similar to those recorded in non-stressed controls. ^##P<0.01 stressed rats compared with non-stressed controls. *P=0.01, **P=0.002 stressed rats receiving DBS compared with non-stimulated stressed animals. Values are means and s.e. Group sizes are indicated in parenthesis. DBS, deep brain stimulation; vmPFC, ventromedial prefrontal cortex.