Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Nov 3;5(11):e674. doi: 10.1038/tp.2015.166

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Temozolomide (TMZ), novelty-suppressed feeding and neurogenesis. (a) Effect of DBS and DBS TMZ in stressed animals calculated as percentage scores in relation to animals given stress alone. Animals receiving DBS had a significant decrease in the latency to feed, an effect that was practically blocked by TMZ (P=0.02). (b) Cell counting revealed that TMZ has virtually reversed a stimulation-induced increase in BrdU+ cells in DBS-treated stressed rats (P=0.004). (c) In addition to group differences in behavioural performance, a significant negative correlation was found between BrdU+ cell counts and latency to feed in the NSFT. (d) Photomicrographs of the hippocampal dentate gyrus illustrating BrdU+ cells (green) dispersed in the granule cell layer (NeuN in red). '*' indicates significant difference between Stress+DBS and non-stimulated stressed animals. '§' indicates significant difference between Stress+DBS and Stress+DBS+TMZ. Values are means and s.e.. Group sizes are indicated in parentheses. Horizontal bar in d, 200 μm. BrdU, 5-bromo-2′-deoxyuridine; DBS, deep brain stimulation; NSFT, novelty-suppressed feeding test.