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. 2015 Sep 22;5(9):e641. doi: 10.1038/tp.2015.126

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Representative MRS voxel-of-interest (VOI) and MRS metabolite levels in adult offspring exposed to prenatal inflammation or saline, with or without n-3 PUFA intervention in peri-adolescence. Representative MRS voxel-of-interest (VOI) and spectra acquired in adult offspring: (a) Voxel-of-interest with the size of 1.2 × 2.6 × 2.5 mm³ was positioned in the anterior cingulate of each mouse. Mouse atlas reference of VOI is from Allen Institute:²⁵ (b) Representative in vivo ¹H spectra with quantum estimation (QUEST) fitting from the anterior cingulate in each group. MRS raw spectrum is shown in black; estimate fitting is shown in red. MRS metabolite levels: (c) Greater N-acetylaspartate (NAA)/creatine (Cr) in n-6 PolyI:C-exposured group compared with all other groups (*P<0.05, **P⩽0.01); n-3 PUFA prevents the rise in NAA/Cr caused by prenatal PolyI:C exposure. (d) Lower myo-inositol (mIns)/Cr in PolyI:C-exposed group compared with Saline group. Groups: n3-POL, prenatal PolyI:C-exposed offspring treated with n-3 PUFA; n6-POL, prenatal PolyI:C-exposed offspring treated with n-6 PUFA; n3-SAL, prenatal saline-exposed offspring treated with n-3 PUFA; n6-SAL, prenatal saline-exposed offspring treated with n6-polyunsaturated fatty acids (n-6 PUFA) control diet. MRS, magnetic resonance spectroscopy; POL, PolyI:C; PUFA, polyunsaturated fatty acids; SAL, saline.