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. 2016 Aug 15;204(2):483–497. doi: 10.1534/genetics.116.189308

Table 1 .

Empirical type I error rate for common correlation structure when β1=1 and all other βj=0 (j1), based on multivariate normal distribution

Sample size No. traits Trait correlation Nominal type I error rate
0.05 0.01
100 4 0.2 0.072 0.020
0.5 0.070 0.016
0.8 0.066 0.014
10 0.2 0.105 0.036
0.5 0.092 0.032
0.8 0.094 0.029
500 4 0.2 0.056 0.017
0.5 0.058 0.011
0.8 0.058 0.009
10 0.2 0.061 0.010
0.5 0.056 0.011
0.8 0.068 0.019
1000 4 0.2 0.052 0.012
0.5 0.058 0.008
0.8 0.051 0.010
10 0.2 0.057 0.012
0.5 0.052 0.010
0.8 0.046 0.007

Underlined values are for when empirical type I error exceeds the upper 95% C.I.