Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jan 12;6(1):e711. doi: 10.1038/tp.2015.191

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

PMC Copyright notice

Representative example of Pearson correlation between 5MC levels at BDNF-ix promoters in the frontal cortex and social interaction (top) and locomotor activity (bottom) in a cohort of control (NS) mice receiving vehicle (Veh), NS mice receiving clozapine (Clz), PRS mice receiving vehicle and PRS mice receiving clozapine. Pearson correlation analyses show a significant negative correlation between promoter methylation and social interaction and a positive correlation between promoter methylation and locomotor activity. Schedule and doses of treatment are as described in Figure 2. The social interaction activity (ratio of sniffing time to the wire cup with vs without the stranger mouse) and the locomotor activity (total number of interruptions of the horizontal sensors in 15 min) were measured 18 h after the last antipsychotic treatment. 5MC and 5HMC promoter enrichment were measured 2 h after the last behavioral test. BDNF, brain-derived neurotrophic factor; 5HMC, 5-hydroxymethylcytosine; 5MC, 5-methylcytosine; NS, nonstressed; PRS, prenatally stressed.