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. 2016 Jan 12;6(1):e711. doi: 10.1038/tp.2015.191

Figure 9.

Figure 9

The increased DNMT1 binding to Gad1, Reln and Bdnf-ix CpG-rich promoter regions is reduced by treatment with clozapine (CLZ) in the frontal cortex of PRS mice, but not haloperidol (HAL). Dose and schedule of drug treatment are described in Figure 2. The values are the mean±s.e.m. analyzed statistically with one-way ANOVA. DNMT1 binding to Gad1, (F5,30=2.48, P=0.048), Reln (F5,30=6.22, P<0.001), Bdnf-ix (F5,30=6.59 P<0.001). *P<0.05 when vehicle (VEH)-treated PRS samples are compared with PRS clozapine-treated samples or to vehicle-treated NS samples. Student–Newman–Keuls multiple comparisons. #P<0.05 when haloperidol-treated PRS samples are compared with PRS clozapine-treated samples or to vehicle-treated NS samples. Student–Newman–Keuls multiple comparisons. ANOVA, analysis of variance; BDNF, brain-derived neurotrophic factor; DNMT1, DNA-methyltransferase 1; NS, nonstressed; PRS, prenatally stressed.