Table 2. Pearson correlation between 5MC and 5HMC at Gadl, Gad2, Rein and Bdnf-ix promoters and social interaction index or motor activity.
| Promoter methylation | Social interaction index | Motor activity |
|---|---|---|
| 5MC-Gadl | R=−0.552, P=0.003 | R=0.548, P=0.005 |
| 5HMC-Gadl | R=−0.668, P=0.0006 | R=0.370, P=0.055 |
| 5MC-Gad2 | R=−0.017, P=0.937 | R=0.220, P=0.300 |
| 5HMC-Gad2 | R=−0.226, P=0.289 | R=0.305, P=0.148 |
| 5MC-Rein | R=−0.580, P=0.004 | R=0.456, P=0.033 |
| 5HMC-Rein | R=−0.450, P=0.027 | R=0.160, P=0.456 |
| 5MC-Bdnf-ix | R=−0.404, P=0.045 | R=0.540, P=0.006 |
| 5HMC-Bdnf-ix | R=−0.529, P=0.008 | R=0.501, P=0.013 |
Abbreviations: BDNF, brain-derived neurotrophic factor; 5HMC, 5-hydroxymethylcytosine; 5MC, 5-methylcytosine; NS, nonstressed; PRS, prenatally stressed.
The Pearson correlation was established in a cohort of 24 animals including 6 control (NS) mice receiving vehicle, 6 NS mice receiving clozapine, 6 PRS mice receiving vehicle, 6 PRS mice receiving clozapine. Bolded entries show significantly significant P-values.