Table 3. Comparison of molecular and behavioral abnormalities in SZ and BP disorder patients and PRS mice.
| SZ and BP | Reference | PRS mice | Reference | |
|---|---|---|---|---|
| Molecular changes | ||||
| GAD67, RELN, BDNF expression | ↓ | 19, 28, 29 | ↓ | 1, 2 |
| DNMT1, 3A and TET1 expression | ↑ | 19, 29 | ↑ | 1, 2 |
| 5MC and 5HMC enrichment at Gadl, Reln and Bdnf promoters | ↑ | 19, 28, 29 | ↑ | Current paper |
| Behavioral changes | ||||
| Positive symptoms (stereotype behaviors, sensitivity to NMDA receptor antagonists) | ↑ | 34, 36 | ↑ | 1, 2 and current paper |
| Negative symptoms (social interactions) | ↓ | 34, 36 | ↓ | 1, 2 and current paper |
| Cognitive, information processing deficit (PPI, fear conditioning) | ↑ | 34, 36 | ↑ | 1, 2 |
Abbreviations: BDNF, brain-derived neurotrophic factor; BP, bipolar; DNMT1, DNA-methyltransferase 1; 5HMC, 5-hydroxymethylcytosine; 5MC, 5-methylcytosine; NMDA, N-methyl d-aspartate; PPI, pre-pulse inhibition; PRS, prenatally stressed; SZ, schizophrenia; TET1, ten-eleven methylcytosine dioxygenase 1.