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. 2016 Jan 12;6(1):e710. doi: 10.1038/tp.2015.201

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Scatter plots illustrate hippocampal: (a) volume; (b) N-acetylaspartate; and (c) fractional anisotropy levels in long-term cannabis users and non-using controls. Controls (n=37) are shown in red. Long-term cannabis users (n=74) comprise three groups: CBDx, those with unknown exposure to CBD (n=19, in brown); CBD−, those known to be exposed to THC but not to CBD (n=30, in green); and CBD+, those exposed to both THC and CBD (n=12, in orange). Former Users, former long-term cannabis users, abstinent for a mean 29 months (n=13, in blue). Horizontal lines represent group means and horizontal bars are the 95% confidence interval. *P<0.05; **P<0.005. Lower panels illustrate the curve-fitting and polynomial contrasts that were applied to the data across the five groups to model our investigational aims.