Figure 3.

Impaired sodium channel function and action potential (AP)-firing ability in Nav1.1-expressing GABAergic neurons. (a) Western blot analysis of total Nav1.1 expression in td⁺ and td⁻ neurons. Unsorted indicates a mixture of td⁺ and td⁻ neurons. (b) Representative traces of sodium currents recorded in td⁺ neurons of patient, control and corrected. Curves of sodium current (I_Na) density (c) and sodium activation (d) of patient (n=16), control (n=12) and corrected (n=14) td⁺ neurons (mean±s.e.m.). (e) Representative traces of APs recorded in td⁺ neurons of patient, control and corrected. Average AP amplitude (f) and firing number (g) for control (n=12), patient (n=11) and corrected (n=13) td⁺ neurons (mean±s.e.m.; *P<0.05, **P<0.01 and ***P<0.001, unpaired t-test).