Table 1. Influence of low activity of tPA and/or protein S on schizophrenia features.

Low activity of tPA and/or protein S
Clinical comorbidity of schizophrenia	Biochemical features of schizophrenia
Cardiovascular risk	Hypercortisolemia
Thrombotic tendency	Elevated cytokine levels
Pregnancy complications	Hyperhomocysteinemia
Lower-than-expected risk of cancer	Hyperinsulinemia
Schizophrenia pathogenesis	Hypertriglyceridemia
Reduced neutrophil	Antiphospholipid antibodies (lupus
Abnormal NMDA receptor activation	anticoagulant and anticardiolipin antibodies)
Dopaminergic hypothesis	Low free-protein S levels?
Adverse fetal environment

Abbreviations: NMDA, N-methyl-D-aspartate; tPA, tissue plasminogen activator.