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. 2016 Jan 12;6(1):e712. doi: 10.1038/tp.2015.206

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Copyright © 2016 Macmillan Publishers Limited

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L100P mice have altered response to changes in sensory deprivation. Monocular deprivation induces a significant shift in ocular dominance index (ODI) in WT mice (a–c) but not in L100P mice (d–f). Plots of ocular dominance index in WT (b) and L100P mice (e) represent the overall contribution of both eyes in the reorganization of the circuitry; for details, see Supplementary Figure 1. (c and f) These panels report the individual contribution of contralateral (contra) and ipsilateral (ipsi) eyes in control (diamonds) and monocularly deprived (MD—triangles) mice, each point has the coordinates of contralateral eye (x) and ipsilateral eye (y). The ocular dominance shift after MD is visible in WT (c), but not in L100P mice (f). *Indicates statistically significant. Scale bar, 0.5 mm. WT, wild type.