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. 2016 Jan 12;6(1):e712. doi: 10.1038/tp.2015.206

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Alteration of PDE4B pathway in L100P mice. (a) PDE4B immunostaining is increased in the brain of L100P mice. Representative images from PFC. (b) Quantification of PDE4B staining across different brain regions shows significant increase of PDE4B expression in L100P mice. (c) cAMP immunostaining is decreased in the brain of L100P mice. Representative images from PFC. (d) Quantification of cAMP staining across different brain regions shows a decreased trend of cAMP expression in L100P mice. Scale bar, 40 μm. *Indicates statistically significant. PFC, prefrontal cortex; WT, wild type.