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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Psychopharmacology (Berl). 2016 Apr 27;233(13):2479–2487. doi: 10.1007/s00213-016-4296-8

Figure 2.

Figure 2

(A) Cumulative antinociceptive dose response curves for fentanyl ip (n=6), fentanyl sc (n=4), VRP26 ip (n=6), and VRP26 sc (n=4) in the mouse warm water tail withdrawal assay. (B) Cumulative antinociceptive dose response curves for VRP26 ip in mu knock-out mice (n=6) and their wild type littermates (n=6) in the mouse warm water tail withdrawal assay (C) Cumulative antinociceptive dose response curves for VRP26 in animals pretreated with vehicle (n=6) or 10 mg/kg methylnaltrexone (MNTX, n=6) a peripherally-restricted opioid antagonist. Data are plotted as mean +/− standard error of the mean (SEM) for all groups.