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. 2016 Aug 5;6(10):3149–3160. doi: 10.1534/g3.116.031583

Figure 6.

Figure 6

Knockdown of genes predicted to be involved with the xenobiotic and endobiotic phase I and phase II system increases anoxia survival in the offspring of hermaphrodites fed a glucose diet. (A) Relative to N2 wild-type controls, RNAi of ugt-63 or cyp-33C8 did not increase anoxia survival in 1 d old adult animals fed a glucose diet. (B) Wild-type adult animals fed a glucose diet (0.25%) produce embryos that are unable to survive anoxia exposure. RNAi of ugt-63 or cyp-33C8 suppressed the anoxia sensitivity observed in embryos from adults fed a glucose diet (*** indicates P < 0.0001 using one-way ANOVA, Tukey multiple comparisons test; at least three independent experiments, with n > 50 embryos per experiment). ANOVA, analysis of variance; RNAi, RNA interference.