Table 3. Locus identified in HMDP by GWAS for ABR phenotypes after noise exposure.
| Traita | Chr | SNPb | Position (Mb)c | −logP | MAF | No. of Genesd |
|---|---|---|---|---|---|---|
| ABR 24 kHz (post) | 6 | rs37517079 | 116.6 | 3.66 × 10−6 | 0.120 | 14 |
| ABR 32 kHz (post) | 6 | rs37517079 | 116.6 | 9.8 × 10−9* | 0.120 | 14 |
*
Genome-wide significant: P < 4.1 × 10−6. MAF, minor allele frequency.
a
ABR postnoise exposure hearing thresholds in different frequencies.
b
The most significant SNP.
c
Locations based on genome assembly (NCBI´s Build37)
d
Number of RefSeq genes (NCBI´s Build37 assembly) located in the mouse association interval. The 95% confidence interval for the distribution of distances between the most significant and the true causal SNPs, for simulated associations that explain 5% of the variance in the HMDP, is 2.6 Mb.