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. 2016 Aug 22;6(10):3317–3333. doi: 10.1534/g3.116.033829

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Copyright © 2016 Guo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mms19-dependent cytosolic iron–sulfur protein assembly and siroheme synthesis are required for cadmium and arsenite resistance. (A) The diagram illustrates the reduction of sulfite to sulfide that is catalyzed by the enzyme sulfite reductase. An Fe–S cluster and siroheme covalently couple with the enzyme to help catalyze the reaction. The requirement for Mms19 in As/Cd resistance most likely reflects its role in promoting Fe–S cluster assembly into the Sir1-Met10 sulfite reductase protein complex. The requirements for siroheme synthase Met8 and the predicted uroporphyrin-3 C-methyltransferase Met1/SPCC1739.06c for cadmium and arsenite resistance most likely reflect their roles in providing siroheme for Sir1-Met10 sulfite reductase. (B) The inability of met8Δ and sua1Δ mutants to grow on synthetic defined media (EMM2) is rescued by supplementation with cysteine.