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. 2016 Aug 22;6(10):3317–3333. doi: 10.1534/g3.116.033829

Table 2. Summary of GO categories enriched by mutants sensitive to arsenite and cadmium (background is protein-encoding genes).

GO Category Fold Enrichment p Value List Frequency (36 genes) Background Frequency (5135 genes) Genes
Biological process
 Sulfur compound metabolic process 15 3.40e−07 27.78% (10) 1.81% (93) SPCC1739.06c, cys2, gcs2, gsa1, met14, cys11, hmt2, sua1, met16, met8
  Sulfur amino acid metabolic process 25 3.11e−05 16.67% (6) 0.66% (34) SPCC1739.06c, cys2, met14, cys11, met16, sua1
  Glutathione biosynthesis 104 2.18e−04 8.33% (3/36) 0.08% (4) gcs2, gsa1, hmt2
 Cofactor biosynthetic process 12 5.30e−5 22.22% (8) 1.85% (95) snz1, SPCC1739.06c, coq3, nde2, coq5, dps1, coq4, coq9, met8
Ubiquinone biosynthetic process 56 6.30e−06 13.89% (5) 0.25% (13) coq9, coq4, coq3, coq5, dps1
Siroheme biosynthetic process 139 4.19e−03 5.56% (2) 0.04% (2) SPCC1739.06c, met8
 Response to metal ion 36 5.02e−04 11.11% (4) 0.31% (16) gsa1, hmt2, pcs2, ccs1
  Phytochelatin biosynthetic process 104 2.18e−04 8.33% (3) 0.08% (4) gsa1, hmt2, pcs2
Cellular component
 Mitochondrion 3 5.73e−03 41.67% (15) 14.10% (724) SPBC660.10, ccs1, cem1, coq3, coq4, coq5, coq9, cys11, cys2, dps1, hmt2, mpc2, nde2, sty1, sua1
  Mitochondrial inner membrane 7 2.02e−03 22.22% (8) 3.17% (163) ccs1, coq3, coq5, coq9, dps1, mpc2, nde2, sty1