Figure 3. Memory-phenotype CD8 T cells that fail to express CD69 or CD25 are preferentially depleted early in sepsis.

(A) At the height of CD44^HI CD8 T cell attrition (24 h), CLP mice demonstrate a significant decrease in the number of DN memory CD8 T cells (left; *P < 0.05), whereas numbers of DN naïve CD8 T cells remain unchanged between sham and sepsis (right). (B) Numbers of DN CD44^HI CD8 T cells are decreased at 6, 24, 48, and 72 h after CLP, mirroring our observations of total numbers of CD44^HI CD8 T cells between sham and sepsis. Results represent independent replicate experiments (n = 5–8/group) and are presented as means ± sem. (*P < 0.05 for all, compared with sham).