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. 2016 Apr 8;100(5):999–1004. doi: 10.1189/jlb.3VMAB1115-496RR

Figure 1. Improved survival by conditional ADAM17 knockout mice during sepsis.

Figure 1.

Conditional ADAM17 knockout (KO) and control mice were subjected to CLP and monitored for 5 d for survival. (A) 18-G, 2-puncture CLP; n = 9 mice per group; P < 0.002, log-rank test. (B) Conditional ADAM17 knockout and control mice were subjected to CLP (18-G, 2-puncture), and sepsis severity was assessed at 12 h using a murine sepsis scoring system to evaluate various physiologic variables, as described in Materials and Methods; n = 9 mice per group; ***P < 0.001. (C) 21-G, 1-puncture CLP; n = 11 mice per group; P < 0.0001, log-rank test.