Table 2.

Cross-sectional baseline differences in mood after adjusting for age, gender and education.

	CSF Aβ42			CSF tau			CSF ptau181
	Lower*	Higher*	p	Lower	Higher	p	Lower	Higher	p
POMS TMD	−4.9 (−6.9 to −2.9)	−6.4 (−8.3 to −4.4)	0.29	−6.1 (−8.0 to −4.1)	−5.2 (−7.2 to −3.1)	0.51	−5.9 (−7.9 to −4.0)	−5.3 (−7.3 to −3.3)	0.66
Anxiety	33.1 (32.1 to 34.2)	32.9 (31.9 to 34.0)	0.80	32.0 (31.8 to 33.9)	33.2 (32.2 to 34.3)	0.64	32.6 (31.6 to 33.7)	33.5 (32.4 to 34.5)	0.27
Vigor	59.7 (57.1 to 62.3)	60.5 (57.9 to 63.0)	0.66	60.3 (57.7 to 62.8)	59.9 (57.3 to 62.5)	0.83	59.9 (57.3 to 62.4)	60.3 (57.7 to 63.0)	0.80
Confusion	38.2 (37.4 to 40.0)	37.1 (36.3 to 37.9)	0.06	37.8 (37.0 to 38.6)	37.5 (36.7 to 38.6)	0.62	37.8 (37.0 to 38.6)	37.5 (36.7 to 38.3)	0.57

	CSF tau/Aβ42			CSF ptau/Aβ42			MCBP for PET PIB
	Lower	Higher	p	Lower	Higher	p	Lower	Higher	p
POMS TMD	−5.8 (−7.8 to −3.8)	−5.5 (−7.0 to −3.5)	0.86	−5.9 (−7.9 to −4.0)	−5.2 (−7.3 to −3.2)	0.63	−6.1 (−8.1 to −4.1)	−5.0 (−7.1 to −3.0)	0.45
Anxiety	33.1 (32.1 to 34.2)	32.8 (31.8 to 33.9)	0.69	32.8 (31.7 to 33.8)	33.4 (32.3 to 34.4)	0.43	32.7 (31.7 to 33.8)	33.5 (32.4 to 34.5)	0.33
Vigor	59.9 (57.3 to 62.5)	60.4 (57.8 to 63.1)	0.78	60.0 (57.4 to 62.5)	60.3 (57.6 to 63.9)	0.87	60.1 (57.6 to 62.7)	60.2 (57.5 to 62.9)	0.95
Confusion	37.3 (36.5 to 38.1)	37.9 (37.1 to 38.8)	0.28	37.4 (36.6 to 38.1)	38.0 (37.2 to 38.8)	0.28	37.4 (36.6 to 38.2)	38.1 (37.3 to 38.9)	0.23

Abbreviations: POMS-SF = Profile of Mood States – Short Form; TMD = Total Mood Disturbance; Aβ₄₂ = β-amyloid₄₂; ptau₁₈₁ = phosphorylated tau₁₈₁; MCBP = Mean Cortical Binding Potential; PiB = Pittsburgh compound B.

^*Mean (95% Confidence Interval)