Table 2.

Pharmakokinetic parameters of oxadiazoles compared to linezolid^a

Drugsb		F (%)	AUC (μg.min/m L)	t½β (h)	CL (mL/min/ kg)	Vd (L/kg)	Tmax (h)	Cmax (μg/mL)
2	iv		2,650	22	18.9	0.37
	po	100	2,620	40			2	2.5
3	iv		3,520	9.6	5.68	4.73
	po	97	4,060	18.6			6	2.34
Linezo lidc	iv		606	0.55	16.3	0.63
	po	72.5	440	0.65			0.33	6.5

^aF - oral bioavailablity; AUC - area under the curve; t_½β- terminal half-life; t_½elim - elimination half-life; CL – clearance; V_d – Volume of distribution; T_max – Time at which peak serum concentration was achieved; C_max – peak serum concentration.

^bCompound 2 was administered iv and po at 50 mg/kg, 3 at 20 mg/kg and linezolid at 10 mg/kg.

^cData reproduced from Slatter et al. 2002 [29] for comparison.