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. Author manuscript; available in PMC: 2017 Oct 11.
Published in final edited form as: Circulation. 2016 Sep 14;134(15):1085–1099. doi: 10.1161/CIRCULATIONAHA.116.023003

Figure 4. Characteristics of the extracellular matrix (ECM).

Figure 4

(A) ECM-based myocardial passive stiffness of muscle strips from LV free wall. The relation of ECM-based stiffness vs. SL of sham (circle), cRbm20ΔRRM-DMSO (upward triangle) and cRbm20ΔRRM-raloxifene (inverted triangle) are shown. ECM-based stiffness was increased in both TAC/DOCA groups. (For analysis, see Supplemental Methods). **p≤0.01; ***p≤0.001 vs. Sham. (n=6, 6, 6 muscle strips from 4, 5, 6 mice for ECM-based passive stiffness.) (B–E) Quantification of collagen in LV myocardium. (B) Representative PSR staining for collagen of LV myocardium. Quantitative analysis showed a similarly increase in collagen volume fraction (C), collagen fiber length (D), and collagen fiber width (E) in both TAC/DOCA groups. **p≤0.01; ****p≤0.0001. (n=9, 14, 21 mice for collagen quantification.)

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