Figure 5. Cardiomyocyte (LV) passive stiffness and slack sarcomere length.
(A) Skinned cardiomyocyte passive stiffness was increased in cRbm20ΔRRM-DMSO but was reduced in cRbm20ΔRRM-raloxifene mice. (For analysis, see Supplemental Methods.) ****p≤0.0001 vs. Sham; ####p≤0.0001 vs. cRbm20ΔRRM-DMSO. (B) Slack sarcomere length of skinned cardiomyocytes (see text for details). ****p≤0.0001 (n=13, 15, 19 cells from 6, 6, 7 mice).