Fig. 4.

a Comparison between CFE-Mean and ICL measured for all 797 AEGs, as determined by default NavX and CARTO EGM settings, respectively. Their respective default thresholds are highlighted (CFE-Mean ≤ 120 ms; ICL ≥ 7). Four quadrants were delimited: two quadrants where ICL and CFE-Mean agreed in terms of categorization, i.e., whether an AEG is fractionated or not fractionated, and two quadrants in which they disagreed. Examples of AEGs for each of the quadrants are shown, to illustrate the characteristics of each group. 230 (out of 797) AEGs with organized activations were found in the non-fractionated agreement zone (green). When looking at the AEGs corresponding to the disagreement quadrants (gray), one notices that they are less organized, still with distinguishable activations. In one gray region (bottom left), 282 AEGs have been classified as CFAEs by NavX but not by CARTO. In the other gray region (top right), 12 AEGs have been classified as CFAEs by CARTO, but not by NavX. Finally, 273 highly fractionated AEGs were found in the CFAE agreement zone (red). The distributions for the AEGs classified as non-CFAEs or CFAEs by both systems, as well as AEGs that had different classifications for each system, are shown according to CFE-Mean (b), ICL (c), CFE-SD (d), ACI (e), and SCI (f). ****P < 0.0001