TABLE 1.
Vaccinia virus titers in mice intranasally immunized two times with rNDV/SIVgag, wild-type rNDV/B1, or PBS
| Immunizationa | Challengeb | Vaccinia virus titer (log 10 PFU/ml)c
|
||||
|---|---|---|---|---|---|---|
| Mouse 1 | Mouse 2 | Mouse 3 | Average | SD | ||
| rNDV/SIVGag | Vac/wt | 8.2 | 8.6 | 8.7 | 8.5 | 0.264575 |
| rNDV/SIVGag | rVac/SIVGag | 5.4 | 5.85 | 6.1 | 5.78 | 0.360555 |
| rNDV/B1 | Vac/wt | 8.8 | 8.35 | 8.6 | 8.58 | 0.225462 |
| rNDV/B1 | rVac/SIVGag | 8.7 | 8.57 | 8.95 | 8.74 | 0.193132 |
| PBS | Vac/wt | 8.3 | 8.5 | 8.8 | 8.53 | 0.251661 |
| PBS | rVac/SIVGag | 8.2 | 8.6 | 8.55 | 8.45 | 0.217945 |
a
Mice immunized with virus received 5 × 107 PFU of virus intranasally at week 0 and week 3.
b
Mice were intranasally challenged at week 6 with 5 × 106 PFU of Vac/wt or rVac/SIVgag virus.
c
Five days after vaccinia virus challenge, mice were sacrificed, and vaccinia virus titers in lungs were determined. Results from three individual mice are shown.