Figure 3.

Cell-Type-Specific Expression

(A) Heatmap showing ε cell enriched gene expression (rows) across the seven cell types for the ten donors (columns). Labels indicating the cell type and donor are shown on the top. Colors in the heatmap correspond to standardized log₂ expression values, where each cell in the heatmap contains the distribution of values across the cells for each cell type and donor.

(B) Heatmap with expression levels of transcription factors (rows) across the cells from the six cell types for the ten donors (columns). Blue and red colors correspond to minimum (zero) and maximum (log₂RPKM = 12) expression, respectively.

(C) Heatmap with expression of significantly enriched genes (rows) in acinar and ductal cells across the six cell types for the ten donors (columns). The genes were selected based on the magnitude of expression range between the two exocrine cell types. The heatmap was generated as in (A).

(D) Heatmap showing the differentially expressed (DE) genes (columns) between the pancreatic stellate (PSCs) and the endothelial cells (rows). The results were obtained using single-cell differential expression (SCDE), and only the genes with a log₂ fold change in expression of at least seven between the two groups are shown. The colors in the heatmap correspond to standardized log₂ expression values, where each cell in the heatmap contains the distribution of values across the cells of each cell type.