Figure 6.

Altered Gene Expression in Cells from T2D Individuals

(A) Bar graphs showing the number of DE genes between cells from healthy and T2D donors per cell type.

(B) Heatmaps with the DE genes between healthy and T2D α (left) and β cells (right). Labels indicating the disease status and sex of the cells are shown on the top. Colors in the heatmap correspond to standardized log₂ expression values, where each cell in the heatmap contains the distribution of values across the cells of each group.

(C) Heatmap of the enriched gene sets (using GSEA) within the α, β, γ, δ, acinar, and ductal cell types for healthy and T2D groups. The heatmap is colored according to the adjusted p values (−log₁₀), with red and blue colors corresponding to enrichments among genes up- and downregulated in T2D, respectively. Sets with no significant enrichment are indicated with white color.