Table 2. Changes of parameters from baseline to after a 6-month weight reduction intervention in all participants.
| Variable | Pre-intervention | After intervention | P value |
|---|---|---|---|
| Body weight, kg | 93.0±17.3 | 87.1±16.2 | <0.01 |
| Body mass index, kg/m2 | 36.9±5.0 | 34.5±4.5 | <0.01 |
| % Body fat, %a | 46.3±9.9 | 44.0±7.8 | 0.14 |
| % Skeletal muscle, %b | 49.5±5.1 | 52.8±5.8 | <0.01 |
| Skeletal muscle indexc | 7.7±1.2 | 7.6±1.2 | 0.19 |
| Leg strength, kg/kg | 1.3±0.4 | 1.4±0.3 | <0.05 |
| Exercise capacity | |||
| ATVO2, mL/min/kg | 11.1±1.8 | 12.2±1.9 | <0.01 |
| Peak VO2, mL/min/kg | 18.7±4.3 | 19.6±4.1 | <0.01 |
| Metabolic parameter | |||
| Visceral fat area, cm2 | 168.8±58.3 | 142.5±40.2 | <0.01 |
| Subcutaneous fat area, cm2 | 465.8±125.0 | 418.0±111.4 | <0.01 |
| HDL-C, mg/dL | 42.1±9.4 | 49.7±8.8 | <0.01 |
| LDL-C, mg/dL | 106.9±29.1 | 113.8±25.3 | 0.06 |
| Triglycerides, mg/dL | 142.6±50.1 | 135.0±52.8 | 0.51 |
| Fasting glucose, mg/dL | 96.8±10.5 | 92.8±7.9 | <0.01 |
| Fasting insulin, μU/mL | 13.8±8.2 | 12.5±7.1 | 0.19 |
| HOMA-IR, ×10-6 mol×IU×L-2 | 3.3±1.8 | 2.8±1.5 | 0.09 |
| HbA1c, % | 5.7±0.5 | 5.7±0.4 | 1.00 |
| Myokine | |||
| Serum irisin, ng/mL | 1.20±0.20 | 1.25±0.18 | 0.14 |
Values are presented as mean±standard deviation. P values are calculated by paired t-test.
ATVO2, anaerobic threshold oxygen uptake; Peak VO2, peak oxygen uptake; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance; HbA1c, glycosylated hemoglobin.
a% Body fat=total fat mass/weight (%), b% Skeletal muscle index=total lean body mass/weight (%), cSkeletal muscle index=lean body mass of extremities/height2 (kg/m2).