Figure 3. Pathway analyses of differentially expressed mRNAs were based on latest KEGG (Kyoto Encyclopedia of Genes and Genomes, http://www.genome.jp/kegg) database.

Most enriched pathway of upregulated (A) and downregulated (B) mRNAs in active infection condition was dominated by immunological networks. Pathway corresponding to upregulated mRNAs in latent infection (C) also includes many immunological networks and pathway corresponding to downregulated mRNAs in latent infection (D) showed enrichment of replication associated pathways. These differentially expressed mRNAs are associated with 155 biological pathways (Supplementary figure 2), where nodes with red color denotes significant association.