Figure 6. CD43⁺ CCR5⁺ CXCR3⁻ Tregs, but not CD43⁺ CCR5⁺ CXCR3⁺ Tregs, exhibit in vivo immunosuppressive activity in inflammatory skin in vivo.

Ear swelling in B6 WT CHS mice at 18 h (left) and over a 24 h time course (right). Mice were adoptively transferred with a no-cell vehicle or CD43⁻ and CD43⁺ CXCR3^+/− CCR5^+/− Treg subsets immediately prior to CHS induction. Data represent means ± SEM. Statistical comparisons were performed by one-way ANOVA with Tukey’s post-hoc test (left) or two-way ANOVA with Bonferroni post-test (right, compared with vehicle control) (* p < 0.05). Illustration was created by R.I. using Power Point software.