Table 1. Characterization of the five Treg subsets defined by CD43, CCR5, and CXCR3.
CD43 | CCR5 | CXCR3 | % in dLNa | Gzmb expression | Il10 expression | Skin infiltration | Skin remaining | Inhibition of CHS response |
---|---|---|---|---|---|---|---|---|
− | 54.5 ± 1.1 | Low | Low | − | − | − | ||
+ | − | − | 19.9 ± 1.0 | Low | Low | + | Low | − |
+ | 9.8 ± 0.4 | High | Low | + | Low | − | ||
+ | − | 4.6 ± 0.5 | High | High | + | High | + | |
+ | 8.4 ± 0.8 | High | High | + | Low | − |
aProportion of each Treg subset among total Tregs isolated from the dLN of CHS mice (mean ± SEM). The data is also presented in Fig. 4A.