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Models for the transport and assembly of the influenza virus RNA polymerase. (A) Subunits PB1, PB2, and PA are transported into the nucleus individually and form a complex in the nucleus. (B) PB1 and PA interact in the cytoplasm and are transported into the nucleus as a dimer. PB2 enters the nucleus as a monomer and binds to PB1-PA in the nucleus. (C) PB1, PB2, and PA interact in the cytoplasm and are transported into the nucleus as a trimeric complex.
