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. 2016 Oct 19;6:35387. doi: 10.1038/srep35387

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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No re-endothelialization of carotid (A–H) and femoral (I–P) arteries with human PBMC-derived CD31+ endothelial cells in NSG mice 4 weeks after reconstitution with 5 × 10⁶ human PBMCs. Sections from sham-operated and injured carotid and femoral arteries obtained from both human PBMC reconstituted (+PBMCs) and non-reconstituted (−PBMCs) NSG mice were included in this analysis. Sections were immunofluorescently stained with anti-human CD31 (hCD31) and anti-mouse CD31 (mCD31) species-specific antibodies. Representative images of arterial staining from 3 different mice per group. Specificity controls for the hCD31 antibody is shown in Fig. S6B. Nuclei were stained with DAPI (blue). Arrowheads indicate positively stained CD31⁺ endothelial cells. Abbreviations: l: lumen; m: media; ni: neointima; PBMCs: human peripheral blood mononuclear cells. Original magnification: 400x.