Table 2.

Plasma PK Parameters of Ixazomib Under Fed and Fasted Conditions

Parameter	Fasted (Reference) (n = 15)	Fed (Test) (n = 15)	Least‐Squares Geometric Mean Ratio (90%CI) (Test/Reference)
Median Tmax, hours (range)	1.02 (0.48‐4.0)	4.0 (1.93‐8.03)
Geometric mean Cmax, ng/mL (%CV)	77.0 (57)	22.8 (54)	0.31 (0.21‐0.45)
Geometric mean AUC0‐216, h · ng/mL (%CV)	1470 (50)	999 (79)	0.72 (0.58‐0.89)

Abbreviations: AUC_0‐216, area under the plasma concentration‐time curve from 0 to 216 hours postdose; CI, confidence interval; C_max, maximum observed plasma concentration; PK, pharmacokinetic; T_max, first time of C_max.