FIG. 6.

VSV replication in hypoxic and hypoxia-adapted cells under single- and multiple-cycle growth conditions. (A) Virus titers determined from cells infected for 22 h at MOI of 10 (white bars) and 0.01 (black bars). Titers shown are the means (± standard deviations) of the results from three separate experiments. (B) Induction of CPE in cells infected at an MOI of 0.01. Cells were infected at an MOI of 0.01, such that ∼1% of cells were initially infected, and at 22 hpi, images were taken. Images are representative of the results from three separate experiments.